News – Page 5 – AKL Therapeutics

AKL and Nordic Bioscience announce collaboration

AKL and Nordic Bioscience Clinical Development, have announced a risk-share agreement to assess the efficacy of a novel, oral medicine, APPA, in a phase II trial of Osteoarthritis (OA). The collaboration was announced at the Osteoarthritis Research Society International (OARSI) World Congress 2019 in Toronto, Canada. The partnership will assess the effectiveness of APPA both […]

An important milestone in the development of APPA

The Phase I clinical trial at Liverpool is designed to test the safety of APPA. The first stage is now complete, and the clinical trial dose escalation committee has approved the transition from a single dose in healthy volunteers to multiple ascending 2 week dosing in osteoarthritis patients. In this part of a clinical trial, […]

More weight loss tied to less knee pain for obese people

A recent article from Reuters Health has highlighted research by the American College of Rheumatology whose researchers have determined that obese people with knee osteoarthritis, a painful joint disease, may find greater symptom relief when they lose larger amounts of weight than when they shed fewer pounds, a recent study suggests. The researchers examined data […]

Phase I Clinical Trial at the University of Liverpool

The Phase I Clinical Trial to test AKL’s lead anti-inflammatory clinical candidate, APPA, as a potential new treatment for osteoarthritis is underway at the University of Liverpool Clinical Trials Unit. The trial has been approved for NIHR support. Osteoarthritis (OA) is the most common type of arthritis in the UK, affecting more than eight million […]

MHRA Approval for Formal Human Trials to Start

The University of Liverpool, as Sponsor of APPA’s clinical program, has received clinical trial authorisation (CTA) from the MHRA (Medicines & Healthcare Products Regulatory Agency) to commence the Phase I clinical trial. The ongoing clinical program will test AKL’s lead candidate, APPA, as a potential new treatment for osteoarthritis. David Sharples, Chief Executive Officer at […]

Under-exploited plants offer untold economic promise

A recent article in Nature by Ameenah Gurib Fakim, President of Mauritius and former Professor of Organic Chemistry, about the abundance of commercially available drugs that have their origins in plants. “Artemisinin, ginkgolides, quinine, reserpine, scopolamine, paclitaxel. What do these molecules have in common? They are all extracted from plants and transformed into useful drugs, […]